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Rx Epizyme Powder Epizyme is activated whole raw pancreas; a pancreatic enzyme concentrate of porcine origin containing standardized amylase protease and lipase activities plus esterases peptidases Nucleases and elastase. Epizyme is used as a digestive aid for replacement therapy where digestion of protein carbohydrate and fat is inadequate due to exocrine pancreatic insufficiency. Made in the USA for dogs and cats. This product requires a prescription.